Association between intraplaque macrophage level and plaque rupture

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591068
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: Tanaka Atsushi 和歌山県立医科大学, 医学部, 准教授 (50458072)
• Co-Investigator(Kenkyū-buntansha): NISHIGUCHI TSUYOSHI 和歌山県立医科大学, 医学部, 学内助教 (40549771)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: ST上昇型心筋梗塞 / 非ST上昇型心筋梗塞 / 光干渉断層法 / マトリックスメタロプロテイナーゼ９ / ミエロペルオキシダーゼ

Outline of Final Research Achievements

Clinical manifestation of ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) has clinical implications for patient management.
Plasma matrix metalloproteinase 9 level in coronary circulation was significantly elevated in patients with STEMI than those with NSTEMI, while plasma myeloperoxidase level was similar between groups. The prevalance of plaque rupture by optical coherence tomography was similar between groups. Coronary MMP-9 level was the independent determinant of STEMI.

Free Research Field

虚血性心疾患