2014 Fiscal Year Final Research Report
Role of HMGB1 protein in the pathogenesis of abdominal aortic aneurysm
Project/Area Number |
24591083
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
ANZAI Toshihisa 独立行政法人国立循環器病研究センター, 病院, 部長 (60232089)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | 循環器・高血圧 / 蛋白質 / 病理学 / 免疫学 |
Outline of Final Research Achievements |
High-mobility group box 1 protein (HMGB1) is a non-histone DNA binding protein and a potent inducer of inflammatory response. We investigated the role of HMGB1 in a mouse CaCl2-induced abdominal aortic aneurysm (AAA) model. Administration of neutralizing anti-HMGB1 antibody for 6 weeks resulted in suppression of AAA formation, inflammatory cellular infiltration, and elastin fragmentation, in association with decreased expression of HMGB1, infiltration of Mac-3 positive macrophages, activity of MMP-2 and MMP-9, and mRNA expression of tumor necrosis factor-α, CD68 and MCP-1 in the aorta. These findings suggest a significant role of HMGB1 in the pathogenesis of AAA through enhanced inflammatory response.
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Free Research Field |
循環器内科学
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