Development of short-term vagus nerve stimulation therapy for the treatment of ventricular remodeling and arrhythmias after myocardial infarction

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591087
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: INAGAKI Masashi 独立行政法人国立循環器病研究センター, 研究所, 室長 (80359273)
• Co-Investigator(Renkei-kenkyūsha): LI Meihua 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 (60443496) ; KAWADA Toru 独立行政法人国立循環器病研究センター, 研究所, 室長 (30243752) ; UEMURA Kazunori 独立行政法人国立循環器病研究センター, 研究所, 室長 (10344350)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 心筋梗塞 / 心不全

Outline of Final Research Achievements

The worldwide prevalence of heart failure that is the final pathway for various cardiovascular diseases is rising with the aging populations, a growing incidence of obesity, and significant healthcare improvements. Myocardial infarction is the most common underlying disease of heart failure, and it has been an important issue how the onset of heart failure is prevented after myocardial infarction. In this study, we developed short-term vagus nerve stimulation therapy for the treatment of ventricular remodeling and arrhythmias after acute myocardial infarction.
Short-term (3days) vagus nerve stimulation after reperfusion therapy reduced myocardial infarction size. Our intravascular vagus nerve stimulation catheter enables less invasive vagus nerve stimulation after acute myocardial infarction.

Free Research Field

循環器病学