2014 Fiscal Year Final Research Report
Reinforcement of infarct scar by targeted transplantation of myofibroblasts reverses postinfarction cardiac remodeling
| Project/Area Number |
24591093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Asahi University (2013-2014)
Gifu University (2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAMORI Hiromitsu 岐阜大学, 医学部附属病院, 講師 (20456502)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Tomoyuki 久留米大学, 医学部, 准教授 (20332687)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | Cell therapy / Heart failure / Integrins / Myocardial infarction / Remodeling |
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| Outline of Final Research Achievements |
The aim of the present study was to prevent the postinfarction left ventricular remodeling and heart failure by autologous cell transplantation. We are performing the experiments in which we intravenously inject the skin-derived myofibroblasts overexpressing integrin beta1 to the mice bearing a large myocardial infarction. Although the results are not conclusive yet, we obtained an excellent results in another similar study in which the intravenously injected endothelial progenitor cells overexpressing integrin beta1 greatly improved the blood flow of ischemic legs of mice.
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| Free Research Field |
循環器内科
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