Insulin signaling as a therapeutic target of heart failure

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591094
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyoto University
• Principal Investigator: SHIOI Tetsuo 京都大学, 医学(系)研究科(研究院), 講師 (50360095)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 心不全 / インスリン / ミトコンドリア

Outline of Final Research Achievements

Heart failure (HF) is associated with changes in energy metabolism of the heart, as well as in extra-cardiac organs such as skeletal muscles. We tested the hypothesis that BCAA ameliorate HF. We used Dahl salt-sensitive (DS) rats fed a high-salt diet as a model of HF. In HF rats, BCAA treatment decreased the heart rate, preserved the cardiac function, and prolonged survival. BCAA also prevented body weight loss, associated with preservation of the skeletal muscle weight. Moreover, the decrease of gene expression related to mitochondrial biogenesis and function was prevented by BCAA in skeletal muscles. In conclusion, BCAA ameliorated HF in a rat model.

Free Research Field

循環器内科学