2014 Fiscal Year Final Research Report
Blockade of TRPC6/3 is a Novel Therapeutic Approach Against Pathological Cardiac Remodeling
| Project/Area Number |
24591095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUWAHARA Koichiro 京都大学, 医学部附属病院循環器内科 (30402887)
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| Co-Investigator(Renkei-kenkyūsha) |
MORI Yasuo 京都大学, 大学院工学研究科
NISHIDA Motohiro 大学共同利用機関法人自然科学研究機構, 心臓シグナル研究部門
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 心不全 |
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| Outline of Final Research Achievements |
In this study, we examined the role of transient receptor potential subfamily C (TRPC) 6/3 in pathological cardiac remodeling.
In model mice of chronic heart failure, blockade of TRPC6/3 significantly attenuated decrease of left ventricular systemic function without affecting blood pressure. Blockade of TRPC6/3 also inhibited PAH and RVH induced in pulmonary hypertension model animals. Blockade of TRPC6/3 could be an novel therapeutic strategy for preventing pathological cardiac remodeling.
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| Free Research Field |
心不全
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