抗加齢に着目した難治性心不全に対する新しい治療法の開発

2013 Fiscal Year Research-status Report

• Project/Area Number: 24591100
• Research Institution: Fukushima Medical University
• Principal Investigator: 竹石 恭知 福島県立医科大学, 医学部, 教授 (40272067)
• Co-Investigator(Kenkyū-buntansha): 及川 雅啓 福島県立医科大学, 医学部, 助教 (30457775) ; 鈴木 聡 福島県立医科大学, 医学部, 助教 (60536944)
• Keywords: 加齢 / 心不全 / 酸化ストレス / ドキソルビシン / アポトーシス / 遺伝子操作マウス

Research Abstract

Senescence Marker Protein-30 (SMP30)は、ノックアウトマウスの解析から抗酸化作用、抗アポトーシス作用を有し抗加齢蛋白として機能していることが示唆されている。心不全の病態に酸化ストレスやアポトーシスは重要な役割を演じている。本研究では、SMP30 の心不全の発症と進展における役割を明らかにし、抗加齢という観点から新しい心不全治療戦略を確立することを目的とする。
今年度はα-myosin heavy chain (MHC) プロモーターを用いて心筋細胞にのみ SMP30 遺伝子を選択的に過剰発現したトランスジェニックマウス (SMP30-TG)と野生型(WT)マウスを用いて、ドキソルビシンに対する SMP30 の作用を検討した。WT マウスと SMP30-TG マウスにドキソルビシンを投与した。ドキソルビシン投与１週後に心エコー検査を行い、サクリファイスして心臓を摘出した。SMP30-TG マウスではWT マウスに比較し、左室駆出率は保持され、線維化率は低下、superoxide 産生は低下、8OHDG 陽性細胞数は減少、caspase-3 活性、Bax/Bcl 比、JNK リン酸化活性は低下した。昨年度の SMP30 ノックアウトマウスを用いた検討とほぼ一致する結果が得られた。心筋細胞に SMP30 を高発現することで、ドキソルビシンによる酸化ストレスの抑制とアポトーシスシグナルの抑制が認められ、SMP30 のドキソルビシンに対する心保護作用を直接的に証明できた。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

心臓選択的に SMP30 遺伝子を高発現したトランスジェニックマウスを用いて、ドキソルビシンに対する SMP30 の心保護効果を証明できた。

Strategy for Future Research Activity

今後は大動脈瘤形成における SMP30 の役割を検討していく予定である。

Expenditure Plans for the Next FY Research Funding

次年度使用額が生じたのは旅費が少なかったためで、研究は順調に進展している。
計画どおりに使用する。

Research Products

• [Journal Article] Diacylglycerol kinase α exacerbates cardiac injury after ischemia/reperfusion (2014)
  • Author(s): Sasaki T, Shishido T, Kadowaki S, Kitahara T, Suzuki S, Katoh S, Funayama A, Netsu S, Watanabe T, Goto K, Takeishi Y, Kubota I
  • Journal Title: Heart and Vessels Volume: 29 Pages: 110-118
  • DOI: 10.1007/s00380-013-0366-6
  • Peer Reviewed
• [Journal Article] Midkine exacerbates pressure overload-induced cardiac remodeling (2014)
  • Author(s): Netsu S, Shishido T, Kitahara T, Honda Y, Funayama A, Narumi T, Kadowaki S, Takahashi H, Miyamoto T, Arimoto T, Nishiyama S, Watanabe T, Woo C, Takeishi Y, Kubota I
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 443 Pages: 205-210
  • DOI: 10.1016/j.bbrc.2013.11.083
  • Peer Reviewed / Open Access
• [Journal Article] Development of takotsubo cardiomyopathy with severe pulmonary edema before a cesarean section (2014)
  • Author(s): Suzuki T, Nemoto C, Ikegami Y, Yokokawa T, Tsukada Y, Abe Y, Shimada J, Takeishi Y, Tase C
  • Journal Title: Journal of Anesthesia Volume: 28 Pages: 121-124
  • DOI: 10.1007/s00540-013-1677-6
  • Peer Reviewed
• [Journal Article] High-sensitivity cardiac troponin T predicts non-cardiac mortality in heart failure (2014)
  • Author(s): Nakamura Y, Yoshihisa A, Takiguchi M, Shimizu T, Yamauchi H, Iwaya S, Owada T, Miyata M, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Circulation Journal Volume: 78 Pages: 890-895
  • DOI: 10.1253/circj.CJ-13-1372
  • Peer Reviewed / Open Access
• [Journal Article] Phosphodiesterase 3A1 protects the heart against angiotensin II-induced cardiac remodeling through regulation of transforming growth factor-β expression (2014)
  • Author(s): Iwaya S, Oikawa M, Yan C, Takeishi Y
  • Journal Title: International Heart Journal Volume: 55 Pages: 165-168
  • DOI: 10.1536/ihj.13-268
  • Peer Reviewed / Open Access
• [Journal Article] Serum tenascin-C level is associated with coronary plaque rupture in patients with acute coronary syndrome (2014)
  • Author(s): Sakamoto N, Hoshino Y, Misaka T, Mizukami H, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Heart and Vessels Volume: 29 Pages: 165-170
  • DOI: 10.1007/s00380-013-0341-2
  • Peer Reviewed
• [Journal Article] Successful revascularization to right coronary artery by percutaneous coronary intervention after endovascular therapy for leriche syndrome (2014)
  • Author(s): Niizeki T, Kaneko K, Sugawara S, Sasaki T, Tsunoda Y, Takeishi Y, Kubota I
  • Journal Title: Clinical Medicine Insights: Case Reports Volume: 7 Pages: 33-36
  • DOI: 10.4137/CCRep.S13551
  • Peer Reviewed / Open Access
• [Journal Article] A case of acute myocardial infarction during perioperative period of non-cardiac surgery in a patient with antiphospholipid syndrome and a history of coronary artery bypass surgery (2014)
  • Author(s): Yokokawa T, Sugimoto K, Iwaya S, Suzuki S, Sakamoto N, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Journal of Cardiology Cases Volume: 9 Pages: 189–191
  • DOI: 10.1016/j.jccase.2014.01.008
  • Peer Reviewed
• [Journal Article] Suppressive effects of adaptive servo-ventilation on ventricular premature complexes with attenuation of sympathetic nervous activity in heart failure patients with sleep-disordered breathing (2014)
  • Author(s): Iwaya S, Yoshihisa A, Nodera M, Owada T, Yamada S, Sato T, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Heart and Vessels Volume: 470-477 Pages: 470-477
  • DOI: 10.1007/s00380-013-0394-2
  • Peer Reviewed
• [Journal Article] Cardiovascular function and prognosis of patients with heart failure coexistent with chronic obstructive pulmonary disease (2014)
  • Author(s): Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Iwaya S, Owada T, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Journal of Cardiology Volume: 64 Pages: 256-264
  • DOI: 10.1016/j.jjcc.2014.02.003
  • Peer Reviewed
• [Journal Article] Somatic 15q break after long-term stable disease in acute myeloid leukemia (2014)
  • Author(s): Harada-Shirado K, Ikeda K, Matsumoto H, Shiga Y, Furukawa M, Takahashi H, Ohkawara H, Noji H, Hashimoto Y, Waguri S, Watanabe S, Ogawa K, Takeishi Y
  • Journal Title: Clinical Lymphoma, Myeloma & Leukemia Volume: 14 Pages: e69-e72
  • DOI: 10.1016/j.clml.2013.10.009
  • Peer Reviewed
• [Journal Article] A new method for maturity-dependent fractionation of neutrophil progenitors applicable for the study of myelodysplastic syndromes (2014)
  • Author(s): Hu H, Shikama Y, Shichishima T, Ikeda K, Akutsu K, Ono T, Kimura H, Ogawa K, Noji H, Takeishi Y, Kimura J
  • Journal Title: Biomarker Research Volume: 2 Pages: 2
  • DOI: 10.1186/2050-7771-2-2
  • Peer Reviewed
• [Journal Article] Efficacy of intrathoracic impedance and remote monitoring in patients with an implantable device after the 2011 great East Japan earthquake (2014)
  • Author(s): Suzuki H, Yamada S, Kamiyama Y, Takeishi Y
  • Journal Title: International Heart Journal Volume: 55 Pages: 53-57
  • DOI: 10.1536/ihj.13-215
  • Peer Reviewed
• [Journal Article] Peripheral blood progenitor cell collection by two programs for autologous and allogeneic transplantation (2014)
  • Author(s): Ikeda K, Ohto H, Kanno T, Gonda K, Suzuki Y, Ono T, Saito S, Takahashi H, Kimura S, Harada-Shirado K, Yamauchi H, Hoshino Y, Mashimo Y, Nollet K, Kikuta A, Ogawa K, Takeishi Y
  • Journal Title: Transfusion Volume: in press Pages: 未定
  • DOI: 10.1111/trf.12437
  • Peer Reviewed
• [Journal Article] Serum cholinesterase is an important prognostic factor in chronic heart failure (2014)
  • Author(s): Sato T, Yamauchi H, Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Heart and Vessels Volume: in press Pages: 未定
  • DOI: 10.1007/s00380-014-0469-8
  • Peer Reviewed
• [Journal Article] Impact of sleep-disordered breathing on myocardial damage and metabolism in patients with chronic heart failure (2014)
  • Author(s): Miyata M, Yoshihisa A, Yamauchi H, Owada T, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Heart and Vessels Volume: in press Pages: 未定
  • DOI: 10.1007/s00380-014-0479-6
  • Peer Reviewed
• [Journal Article] Comparisons of prognostic factors between young and elderly patients with chronic heart failure (2014)
  • Author(s): Sato T, Yamauchi H, Kanno Y, Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Geriatrics and Gerontology International Volume: in press Pages: 未定
  • DOI: 10.1111/ggi.12293
  • Peer Reviewed
• [Journal Article] Acute heart failure volume control multicenter randomized (AVCMA) trial: Comparison of tolvaptan and carperitide (2013)
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saito T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y, on behalf of the AVCMA investigators
  • Journal Title: Journal of Clinical Pharmacology Volume: 53 Pages: 1277-1285
  • DOI: 10.1002/jcph.197
  • Peer Reviewed
• [Journal Article] Adaptive servoventilation improves cardiorenal function and prognosis in heart failure patients with chronic kidney disease and sleep-disordered breathing (2013)
  • Author(s): Owada T, Yoshihisa A, Yamauchi H, Iwaya S, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Journal of Cardiac Failure Volume: 19 Pages: 225-232
  • DOI: 10.1016/j.cardfail.2013.03.005
  • Peer Reviewed
• [Journal Article] Age-related oxidant stress with senescence marker protein-30 deficiency plays a pivotal role in coronary artery spasm (2013)
  • Author(s): Hoshino Y, Yamada S, Saitoh S, Machii H, Mizukami H, Miyata M, Misaka T, Ishigami A, Takeishi Y
  • Journal Title: Coronary Artery Disease Volume: 24 Pages: 110-118
  • DOI: 10.1097/MCA.0b013e32835c8f96
  • Peer Reviewed
• [Journal Article] Cardiac nuclear high mobility group box 1 prevents the development of cardiac hypertrophy and heart failure (2013)
  • Author(s): Funayama A, Shishido T, Netsu S, Narumi T, Kadowaki S, Takahashi H, Miyamoto T, Watanabe T, Woo C, Abe J, Kuwahara K, Nakao K, Takeishi Y, Kubota I
  • Journal Title: Cardiovascular Research Volume: 99 Pages: 657-664
  • DOI: 10.1093/cvr/cvt128
  • Peer Reviewed
• [Journal Article] Clinical features of patients with decompensated heart failure after the Great East Japan Earthquake (2013)
  • Author(s): Yamauchi H, Yoshihisa A, Iwaya S, Owada T, Sato T, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: American Journal of Cardiology Volume: 112 Pages: 94-99
  • DOI: 10.1016/j.amjcard.2013.02.057
  • Peer Reviewed
• [Journal Article] Coronary artery spasm related to thiol oxidation and senescence marker protein-30 in aging (2013)
  • Author(s): Yamada S, Saitoh S, Machii H, Mizukami H, Hoshino Y, Misaka T, Ishigami A, Takeishi Y
  • Journal Title: Antioxidants & Redox Signaling Volume: 19 Pages: 1063-1073
  • DOI: 10.1089/ars.2012.4903
  • Peer Reviewed
• [Journal Article] DDTA mode pacing in the treatment of complete conduction block from the right atrium to the ventricles and interatrial electrical dissociation after surgical procedures (2013)
  • Author(s): Nakamura Y, Suzuki H, Takeda H, Takeishi Y
  • Journal Title: Journal of Arrhythmia Volume: 29 Pages: 235-237
  • DOI: 10.1016/j.joa.2012.12.005
  • Peer Reviewed
• [Journal Article] Deep seating of 5 Fr. guiding catheter across the stenosis with 5 in 7 method was effective for severely calcified lesion (2013)
  • Author(s): Hoshino Y, Kunii H, Misaka T, Mizukami H, Yoshihisa A, Sakamoto N, Sugimoto K, Nakazato K, Saitoh S, Takeishi Y
  • Journal Title: Cardiovascular Intervention and Therapeutics Volume: 28 Pages: 87-90
  • DOI: 10.1007/s12928-012-0119-y
  • Peer Reviewed
• [Journal Article] Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodelling (2013)
  • Author(s): Misaka T, Suzuki S, Miyata M, Kobayashi A, Shishido T, Ishigami A, Saitoh S, Hirose M, Kubota I, Takeishi Y
  • Journal Title: Cardiovascular Research Volume: 9 Pages: 461-470
  • DOI: 10.1093/cvr/cvt122
  • Peer Reviewed
• [Journal Article] Distinct prognostic factors in patients with chronic heart failure and chronic kidney disease (2013)
  • Author(s): Sato T, Yamauchi H, Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: International Heart Journal Volume: 54 Pages: 311-317
  • DOI: 10.1536/ihj.54.311
  • Peer Reviewed
• [Journal Article] Impact of adaptive servo-ventilation on cardiovascular function and prognosis in heart failure patients with preserved left ventricular ejection fraction and sleep-disordered breathing (2013)
  • Author(s): Yoshihisa A, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: European Journal of Heart Failure Volume: 15 Pages: 543-550
  • DOI: 10.1093/eurjhf/hfs197
  • Peer Reviewed
• [Journal Article] Impairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome patients (2013)
  • Author(s): Feng X, Shikama Y, Shichishima T, Noji H, Ikeda K, Ogawa K, Kimura H, Takeishi Y, Kimura J
  • Journal Title: PLoS One Volume: 8 Pages: e61107
  • DOI: 10.1371/journal.pone.0061107
  • Peer Reviewed
• [Journal Article] Left ventricular plasty improved cardiac function in a case of takotsubo cardiomyopathy with persistent aneurysm (2013)
  • Author(s): Miyata M, Nakazato K, Sakamoto N, Suzuki S, Kamiyama Y, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Journal of Cardiology Cases Volume: 7 Pages: e133-e136
  • DOI: 10.1016/j.jccase.2012.12.007
  • Peer Reviewed
• [Journal Article] Long pentraxin PTX3 exacerbates pressure overload–induced left ventricular dysfunction (2013)
  • Author(s): Suzuki S, Shishido T, Funayama A, Netsu S, Ishino M, Kitahara T, Sasaki T, Katoh S, Otaki Y, Watanabe T, Shibata Y, Mantovani A, Takeishi Y, Kubota I
  • Journal Title: PLoS One Volume: 8 Pages: e53133
  • DOI: 10.1371/journal.pone.0053133
  • Peer Reviewed
• [Journal Article] New angiotensin II type 1 receptor blocker, azilsartan, attenuates cardiac remodeling after myocardial infarction (2013)
  • Author(s): Nakamura Y, Suzuki S, Saitoh S, Takeishi Y
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 36 Pages: 1326-1331
  • DOI: 10.1248/bpb.b13-00194
  • Peer Reviewed
• [Journal Article] Pulmonary hypertension and refractory heart failure in a patient with Crow-Fukase (POEMS) syndrome (2013)
  • Author(s): Yokokawa T, Nakazato K, Kanno Y, Mizukami H, Kobayashi A, Yoshihisa A, Takahashi H, Shichishima-Nakamura A, Ohkawara H, Noji H, Suzuki H, Saitoh S, Ogawa K, Hisa S, Takeishi Y
  • Journal Title: Internal Medicine Volume: 52 Pages: 1061-1065
  • DOI: 10.2169/internalmedicine.52.9256
  • Peer Reviewed
• [Journal Article] Senescence marker protein-30 (SMP30) deficiency impairs Myocardium-induced dilation of coronary arterioles associated with reactive oxygen species (2013)
  • Author(s): Mizukami H, Saitoh S, Machii H, Yamada S, Hoshino Y, Misaka T, Ishigami A, Takeishi Y
  • Journal Title: International Journal of Molecular Science Volume: 14 Pages: 9408-9423
  • DOI: 10.3390/ijms14059408
  • Peer Reviewed
• [Journal Article] Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction (2013)
  • Author(s): Misaka T, Suzuki S, Miyata M, Kobayashi A, Ishigami A, Shishido T, Saitoh S, Kubota I, Takeishi Y
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 439 Pages: 142-147
  • DOI: 10.1016/j.bbrc.2013.08.002
  • Peer Reviewed
• [Journal Article] Senescence marker protein 30 has a cardio-protective role in doxorubicin-induced cardiac dysfunction (2013)
  • Author(s): Miyata M, Suzuki S, Misaka T, Shishido T, Saitoh S, Ishigami A, Kubota I, Takeishi Y
  • Journal Title: PLoS One Volume: 8 Pages: e79093
  • DOI: 10.1371/journal.pone.0079093
  • Peer Reviewed
• [Journal Article] Short-term use of adaptive servo ventilation improves renal function in heart failure patients with sleep-disordered breathing (2013)
  • Author(s): Yoshihisa A, Suzuki S, Owada T, Iwaya S, Yamauchi H, Miyata M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Heart and Vessels Volume: 28 Pages: 728-734
  • DOI: 10.1007/s00380-012-0303-0
  • Peer Reviewed
• [Journal Article] Sleep-disordered breathing increases risk for fatal ventricular arrhythmias in patients with chronic heart failure (2013)
  • Author(s): Yamada S, Suzuki H, Kamioka M, Suzuki S, Kamiyama Y, Yoshihisa A, Saitoh S, Takeishi Y
  • Journal Title: Circulation Journal Volume: 77 Pages: 1466-1473
  • DOI: 10.1253/circj.CJ-12-0836
  • Peer Reviewed
• [Journal Article] Soluble amyloid precursor protein 770 is a novel biomarker candidate for acute coronary syndrome (2013)
  • Author(s): Kitazume S, Yoshihisa A, Yamaki T, Oikawaa M, Tachida Y, Ogawa K, Imamaki R, Takeishi Y, Yamamoto N, Taniguchi N
  • Journal Title: Proteomics Clinical Applications Volume: 7 Pages: 657-663
  • DOI: 10.1002/prca.201200135
  • Peer Reviewed
• [Journal Article] Start and initial results of the Fukushima prefecture acute myocardial infarction registration survey (2013)
  • Author(s): Nakazato K, Yamaki T, Takeishi Y, et al
  • Journal Title: Fukushima Journal of Medical Science Volume: 59 Pages: 27-34
  • DOI: 10.5387/fms.59.27
  • Peer Reviewed
• [Journal Article] Usefulness of albuminuria as a prognostic indicator in patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy (2013)
  • Author(s): Niizeki T, Takeishi Y, Sasaki T, Kaneko K, Sugawara S, Watanabe T, Kubota I
  • Journal Title: American Journal of Cardiology Volume: 111 Pages: 1180-1186
  • DOI: 10.1016/j.amjcard.2012.12.050
  • Peer Reviewed
• [Journal Article] Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury (2013)
  • Author(s): Oikawa M, Wu M, Lim S, Knight W, Miller C, Cai Y, Lu Y, Blaxall B, Takeishi Y, Abe J, Yan C
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 64 Pages: 11-19
  • DOI: 10.1016/j.yjmcc.2013.08.003
  • Peer Reviewed
• [Journal Article] 福島県急性心筋梗塞発症登録調査2012年集計 (2013)
  • Author(s): 八巻尚洋, 中里和彦, 竹石恭知, 他
  • Journal Title: 福島県医師会報 Volume: 75 Pages: 599-605
• [Presentation] 心膜下脂肪厚は冠動脈病変と関連する -心エコー法と心臓CTによる比較検討-
  • Author(s): 及川雅啓, 小林 淳, 大和田卓史, 山内宏之, 三阪智史, 竹石恭知
  • Organizer: 第24回 日本心エコー図学会学術集会
  • Place of Presentation: 東京
• [Presentation] T-wave alternans is useful for predicting adverse outcomes of hospitalized patients with heart failure
  • Author(s): Yamada S, Suzuki H, Kaneshiro T, Kamiyama Y, Saitoh S, Takeishi Y
  • Organizer: Heart Rhythm 2013, 34th Annual Scientific Sessions
  • Place of Presentation: Denver, Colorado, USA
• [Presentation] 慢性心不全のマネージメント
  • Author(s): 竹石恭知
  • Organizer: 第17回 山形いちごの会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Breast tumor as a presentation of extranodal T-cell lymphoblastic lymphoma-clinical and pathological analysis
  • Author(s): Harada-Shirado K, Ikeda K, Hashimoto Y, Kawana S, Matsumoto H, Ohkawara H, Noji H, Abe M, Ogawa K, Takeishi Y
  • Organizer: The 4th JSH International Symposium 2013 in Ehime
  • Place of Presentation: Matsuyama, Japan
• [Presentation] Solubule smyloid precrsor protein 770 is secreted in a O-glycosylated form from inflamed endothelial cells
  • Author(s): Kitazume S, Yoshihisa A, Yamaki T, Oikawa M, Tachida Y, Ogawa K, Imamaki R, Hagiwara Y, Kinoshita N, Takeishi Y, Iwata N, Saido T, Yamamoto N, Taniguchi N
  • Organizer: 22nd International Symposium on Glycoconjugates
  • Place of Presentation: Dalian, China
• [Presentation] Phosphodiesterase 3A1 protects the heart against angiotensin II-induced cardiac remodeling via regulating interaction between β-adrenergic and angiotensin II pathways
  • Author(s): Oikawa M, Iwaya S, Yan C, Takeishi Y
  • Organizer: The 30th Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: San Diego, USA
• [Presentation] The mapping strategy associated with QRS morphology in the patients with idiopathic ventricular tachycardia and ventricular premature contraction
  • Author(s): Kaneshiro T, Suzuki H, Yamada S, Kamiyama Y, Takeishi Y
  • Organizer: 第28回 日本不整脈学会学術大会
  • Place of Presentation: 東京
• [Presentation] Changes of serum phosphate levels have prognostic impacts in chronic heart failure patients with cardiac resynchronization therapy
  • Author(s): Kamiyama Y, Suzuki H, Yamada S, Kaneshiro T, Takeishi Y
  • Organizer: 第28回 日本不整脈学会学術大会
  • Place of Presentation: 東京
• [Presentation] Possible multiple organ damages in patients with peripheral arterial disease
  • Author(s): Nakamura Y, Kunii H, Masuda A, Mizukami H, Oikawa M, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第22回 日本心血管インターベンション治療学会学術集会
  • Place of Presentation: 神戸市
• [Presentation] Consideration of intravascular ultrasound predictors of side branch occlusion in bifurcation lesions after stent crossover technique
  • Author(s): Sakamoto N, Mizukami H, Yamaki T, Kunii H, Nakazato K, Takeishi Y
  • Organizer: 第22回 日本心血管インターベンション治療学会学術集会
  • Place of Presentation: 神戸市
• [Presentation] 運動耐容能と運動時周期性呼吸は慢性心不全患者の独立した予後予測因子である
  • Author(s): 山内宏之, 佐藤崇匡, 菅野優紀, 中里和彦, 鈴木 均, 斎藤修一, 竹石恭知
  • Organizer: 第19回 日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 仙台市
• [Presentation] Clinical features of patients with decompensated heart failure after the Great East Japan Earthquake
  • Author(s): Yamauchi H, Yoshihisa A, Owada T, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2013
  • Place of Presentation: Amsterdam, The Netherlands
• [Presentation] Acute heart failure volume control trial: the comparison of tolvaptan and carperitide
  • Author(s): Suzuki S, Yoshihisa A, Abe Y, Saito T, Ohwada T, Kubota I, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2013
  • Place of Presentation: Amsterdam, The Netherlands
• [Presentation] 心不全の体液コントロール -水利尿薬の役割- 急性心不全治療における水利尿薬の役割
  • Author(s): 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
  • Invited
• [Presentation] 心不全における収縮不全と拡張不全のトピックス 心不全（収縮不全及び拡張不全）に合併する睡眠呼吸障害に対する陽圧換気療法の心・腎・血管機能に対する効果
  • Author(s): 義久精臣, 鈴木 聡, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] 循環器疾患を生活リズムと睡眠呼吸障害から考える 心不全に合併する睡眠呼吸障害の影響及び治療効果ー自律神経機能、不整脈への影響ー
  • Author(s): 義久精臣, 山田慎哉, 鈴木 聡, 鈴木 均, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] Heart Risk Viewで解析した症例における3年間心事故の実際
  • Author(s): 斎藤富善, 根岸紘子, 佐藤彰彦, 泉田次郎, 斎藤恒義, 前原和平, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] 心膜下脂肪厚は冠動脈病変と関連する -心エコー法と心臓CTによる比較検討-
  • Author(s): 及川雅啓, 小林 淳, 大和田卓史, 山内宏之, 宮田真希子, 三阪智史, 待井宏文, 斎藤修一, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] 抗リン脂質抗体症候群を合併した冠動脈バイパス術後患者の非心臓手術周術期に急性心筋梗塞を来した1例
  • Author(s): 横川哲朗, 杉本浩一, 岩谷章司, 鈴木 聡, 坂本信雄, 中里和彦, 鈴木 均, 斎藤修一, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] 慢性心不全患者における退院後腎機能悪化の予測因子
  • Author(s): 山内宏之, 佐藤崇匡, 菅野優紀, 義久精臣, 中里和彦, 鈴木 均, 斎藤修一, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] 福島市におけるLMT病変に対するステント治療成績
  • Author(s): 水上浩行, 中里和彦, 大竹秀樹, 坂本信雄, 八巻尚洋, 國井浩行, 大和田尊之, 阿部之彦, 鈴木 均, 斎藤修一, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] PCI後に原因不明の右大腿部腫瘤が出現した一例
  • Author(s): 肘岡奈保子, 新妻健夫, 野寺 穣, 金澤晃子, 遠藤教子, 小松宣夫, 武田寛人, 丹治雅博, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] 急性非代償性心不全における 'cold' を呈する患者の特徴
  • Author(s): 佐藤崇匡, 山内宏之, 菅野優紀, 義久精臣, 中里和彦, 鈴木 均, 斎藤修一, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] 慢性心不全患者における増悪時体重増加と患者背景の検討
  • Author(s): 菅野優紀, 佐藤崇匡, 山内宏之, 義久精臣, 中里和彦, 鈴木 均, 斎藤修一, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] 小林 淳, 及川雅啓, 中里和彦, 鈴木 均, 斎藤修一, 竹石恭知
  • Author(s): 感染性心内膜炎患者における術後抗生剤投与と炎症マーカーの関連性の検討
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] 完全房室ブロックにて発症し、心内血栓を認めた心サルコイドーシスの１例
  • Author(s): 佐藤 悠, 小林 淳, 渡邊俊介, 大和田卓史, 金城貴士, 中里和彦, 鈴木 均, 斎藤修一, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] QRS幅正常であるアドリアマイシン心筋症に対してCRT-D植え込みを行い、心機能の著名な改善が得られた1例
  • Author(s): 阿部諭史, 鈴木 均, 大和田卓史, 金城貴士, 神山美之, 八巻尚洋, 竹石恭知
  • Organizer: 第30回 日本心電学会学術集会
  • Place of Presentation: 青森市
• [Presentation] 慢性血栓塞栓性肺高血圧症に対する肺動脈バルーン拡張術前後の心電図変化の特徴
  • Author(s): 神雄一朗, 金城貴士, 鈴木 均, 神山美之, 小林 淳, 杉本浩一, 中里和彦, 竹石恭知
  • Organizer: 第30回 日本心電学会学術集会
  • Place of Presentation: 青森市
• [Presentation] Successful percutaneous coronary intervention for acute myocardial infarction due to compression of left main trunk by a false lumen of acute ascending-aortic dissection seven years after partial ascending-aorta replacement and aortic valve replacement
  • Author(s): Kunii H, Kokubun T, Nakamura Y, Mizukami H, Oikawa M, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Transcatheter Cardiovascular Therapeutics (TCT) 2013
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] 循環器疾患の診断・急性期治療
  • Author(s): 竹石恭知
  • Organizer: 第20回 日本航空医療学術総会
  • Place of Presentation: 福島市
  • Invited
• [Presentation] Senescence marker protein 30 has a cardio-protective role in doxorubicin-induced cardiac dysfunction
  • Author(s): Miyata M, Suzuki S, Misaka T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Cyclic variation of heart rate score by holter ECG for screening sleep disordered breathing in heart failure patients
  • Author(s): Shimizu T, Yoshihisa A, Iwaya S, Miyata M, Abe S, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Liver dysfunction assessed by model of end-stage liver disease excluding INR (MELD-XI) scoring system predicts adverse prognosis in heart failure
  • Author(s): Shimizu T, Yoshihisa A, Takiguchi M, Yamauchi H, Owada T, Iwaya S, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Adaptive servo-ventilation therapy improves long-term prognosis in heart failure patients with anemia and sleep-disordered breathing
  • Author(s): Suzuki S, Yoshihisa A, Shimizu T, Yamauchi H, Owada T, Miyata M, Abe S, Sato T, Yamaki T, Sugimoto K, Kunii H, Nakazto K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Vasopressin V2 receptor antagonist tolvaptan is effective in heart failure patients with reduced cardiac systolic function
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saito T, Ohwada T, Saitoh S, Kubota I, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Severity of airflow limitation predicts exercise capacity and adverse clinical outcomes in chronic heart failure
  • Author(s): Sato T, Yamauchi H, Kanno Y, Suzuki S, Yoshihisa A, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Miyata M, Yoshihisa A, Shimizu T, Iwaya S, Owada T, Abe S, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Author(s): Sleep-disordered breathing exacerbates ongoing myocardial damage in patients with heart failure
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Senescence marker protein-30 deficiency impairs collateral growth under ischemia in aging
  • Author(s): Yamauchi H, Saitoh S, Owada T, Yamada S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Identification of thrombus in left atrial appendage by 320-row ADCT confirms the optimal strategy of CHA2DS2-VASc score for initiating anticoagulation treatment in patients with atrial fibrillation
  • Author(s): Ishibashi T, Sato M, Machii H, Yamaguchi O, Moriya H, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Follow-up of earthquake-induced acute decompensated heart failure and related risk factors in the great east Japan earthquake
  • Author(s): Suzuki H, Yamauchi H, Owada T, Yoshihisa A, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Impact of sleep-disordered breathing on vascular dysfunction and ventricular arrhythmias in heart failure patients
  • Author(s): Yoshihisa A, Suzuki S, Yamada S, Suzuki H, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Senescence marker protein 30 has protective effects on angiotensin II-induced cardiac hypertrophy and diastolic dysfunction
  • Author(s): Suzuki S, Misaka T, Saitoh S, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Predictors of improved renal function after discharge in chronic heart failure
  • Author(s): Sato T, Yamauchi H, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Abe S, Yoshihisa A, Yamauchi H, Owada T, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Takeishi Y
  • Author(s): Cardiac function in heart failure patients with chronic obstructive pulmonary diseases
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Adaptive servo ventilation improves cardio-renal function and prognosis in heart failure patients with chronic kidney disease and sleep disordered breathing
  • Author(s): Owada T, Yoshihisa A, Sato T, Suzuki S, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Takiguchi M, Yoshihisa A, Shimizu T, Yamauchi H, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Takeishi Y
  • Author(s): Cardiac function in heart failure patients with periodic leg movements
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Utility of cyclic variation of heart rate score by holter ECG for screening sleep disordered breathing in heart failure patients
  • Author(s): Shimizu T, Yoshihisa A, Iwaya S, Miyata M, Abe S, Sato T, Suzuki S, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Sleep-disordered breathing exacerbates ongoing myocardial damage in patients with heart failure
  • Author(s): Miyata M, Yoshihisa A, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] The role of deregulated HMGA2 expression with promoter methylation of p16 in myeloproliferative neoplasms
  • Author(s): Shirado-Harada K, Ikeda K, Ogawa K, Noji H, Kimura H, Kai T, Morishita S, Komatsu N, Takeishi Y
  • Organizer: 2013 American Society of Hematology (ASH) Annual Meeting and Exposition
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] Ineffective erythropoiesis with increased neutrophils in old mice overexpressing Hmga2 cDNA
  • Author(s): Ikeda K, Mason P, Shirado-Harada K, Ogawa K, Bessler M, Takeishi Y
  • Organizer: 2013 American Society of Hematology (ASH) Annual Meeting and Exposition
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] 心筋血流イメージング
  • Author(s): 竹石恭知
  • Organizer: 日本心臓核医学会 東北地域教育研修会
  • Place of Presentation: 仙台市
  • Invited
• [Presentation] 心臓病治療の現状と展望
  • Author(s): 竹石恭知
  • Organizer: F-S. T. R. Learning Conference
  • Place of Presentation: 福島市
  • Invited
• [Presentation] 腎不全に心不全・呼吸不全を合併した患者の血液浄化法とその管理（血液浄化心不全研究会との合同企画): 心不全合併CKD患者のASV(Adaptive-Servo Ventilation)療法による心腎機能改善効果
  • Author(s): 義久精臣, 鈴木 聡, 竹石恭知
  • Organizer: 第41回 日本集中治療医学会学術集会
  • Place of Presentation: 京都市
• [Presentation] 心臓病治療の現況と展望
  • Author(s): 竹石恭知
  • Organizer: 第200回 県北循環器疾患研究会
  • Place of Presentation: 福島市
  • Invited
• [Presentation] Diacylglycerol kinase ζ attenuates doxorubicin-induced cardiotoxicity through inhibition of pro-apoptotic protein p53 and subsequent apoptosis
  • Author(s): Otaki Y, Takahashi H, Watanabe T, Yokoyama M, Kinoshita D, Narumi T, Kadowaki S, Honda Y, Arimoto T, Shishido T, Miyamoto T, Takeishi Y, Kubota I
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Increased acute myocardial infarction mortality after the Great East Japan Earthquake: an analysis of death certificate data
  • Author(s): Takegami M, Miyamoto Y, Yasuda S, Nishimura K, Nakamura M, Takeishi Y, Hirata K, Morino Y, Ogawa H, Shimokawa H, Naito H
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Endogenous carbon monoxide is helpful to develop collateral flow in acute myocardial infarction
  • Author(s): Kobayashi A, Mizukami H, Sakamoto N, Yamaki T, Kunii H, Nakazato K, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Epicardial adipose tissue reflects the presence of coronary artery disease: comparison with abdominal visceral adipose tissue
  • Author(s): Oikawa M, Owada T, Yamauchi H, Misaka T, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Acute heart failure volume control multicenter randomized (AVCMA) trial: comparison of tolvaptan and carperitide
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saito T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Severity of airflow limitation predicts exercise capacity and adverse clinical outcomes in chronic heart failure
  • Author(s): Sato T, Yamauchi H, Kanno Y, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Cyclic variation of heart rate score by Holter ECG for screening sleep disordered breathing in heart failure patients
  • Author(s): Shimizu T, Yoshihisa A, Iwaya S, Nakamura Y, Miyata M, Abe S, Satoh T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Sleep-disordered breathing exacerbates ongoing myocardial damage in patients with heart failure
  • Author(s): Takiguchi M, Yoshihisa A, Shimizu T, Yamauchi H, Owada T, Iwaya S, Nakamura Y, Miyata M, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Influence of sleep disordered breathing on heart rate turbulence in heart failure patients
  • Author(s): Shimizu T, Yoshihisa A, Abe S, Takiguchi M, Iwaya S, Nakamura Y, Miyata M, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Autonomic nervous imbalance influences a new onset heart failure in patients with hypertension in Minamisoma City after catastrophic disasters
  • Author(s): Yamada S, Suzuki H, Misak T, Mizukami H, Sugimoto K, Saitoh S, Suzuki F, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Comparisons of prognostic factors between patients with ischemic and non-ischemic etiology in chronic heart failure
  • Author(s): Sato T, Yamauchi H, Kanno Y, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Tolvaptan is effective in heart failure patients with reduced left ventricular systolic function
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saitoh T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Exercise capacity is a strong factor to predict responders to cardiac resynchronized therapy and prognosis
  • Author(s): Yamauchi H, Satoh T, Kanno Y, Yoshihisa A, Kaneshiro T, Kamiyama Y, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Model of end-stage liver disease excluding INR (MELD-XI) scoring system for liver function predicts adverse prognosis in heart failure
  • Author(s): Abe S, Yoshihisa A, Takiguchi M, Shimizu T, Yamauchi H, Owada T, Iwaya S, Miyata M, Satoh T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Prognostic value of clinical SYNTAX score for risk assessment in patients with left main trunk disease
  • Author(s): Mizukami H, Nakazato K, Ohtake H, Sakamoto N, Yamaguchi O, Yamaki T, Kunii H, Ohwada T, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Strategy and its angiographic follow-up result for left main trunk in Fukushima City
  • Author(s): Mizukami H, Nakazato K, Ohtake H, Sakamoto N, Yamaguchi O, Yamaki T, Kunii H, Ohwada T, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Long-term prognosis in acute decompensated heart failure patients treated with tolvaptan: The AVCMA trial
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saitoh T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Cardiovascular function and prognosis of patients with heart failure coexistent with chronic obstructive pulmonary disease
  • Author(s): Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Iwaya S, Miyata M, Abe S, Satoh T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Cardio-vascular function in heart failure patients with periodic leg movements
  • Author(s): Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Iwaya S, Miyata M, Abe S, Satoh T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Book] Aging and Heart Failure (2014)
  • Author(s): Takeishi Y
  • Total Pages: 243-247
  • Publisher: Springer
• [Book] Aging and Heart Failure (2014)
  • Author(s): Suzuki S, Takeishi Y
  • Total Pages: 457-463
  • Publisher: Springer
• [Book] 循環器疾患最新の治療 2014-2015 (2014)
  • Author(s): 竹石恭知
  • Total Pages: 119-120
  • Publisher: 南江堂
• [Book] 徹底ガイド 心不全Q&A -プレホスピタルから慢性期まで- [第2版] (2013)
  • Author(s): 義久精臣, 小林 淳, 竹石恭知
  • Total Pages: 71-78
  • Publisher: 総合医学社
• [Book] 心臓リハビリテーション (2013)
  • Author(s): 神山美之, 竹石恭知
  • Total Pages: 82-90
  • Publisher: 医歯薬出版株式会社