2014 Fiscal Year Final Research Report
Investigation of anemia and iron metabolism in chronic heart failure
| Project/Area Number |
24591103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAITO Yoshiro 兵庫医科大学, 医学部, 講師 (10446049)
MASUYAMA Tohru 兵庫医科大学, 医学部, 教授 (70273670)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 慢性心不全 / 貧血 / 心腎貧血症候群 |
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| Outline of Final Research Achievements |
Anemia and iron deficiency are associated with poor prognosis in patients with chronic heart failure (CHF). The aim of the study is to investigate the mechanism and treatment of them in CHF. We have previously reported that anemia and iron deficiency are induced by high salt diet in Dahl salt-sensitive hypertensive (DS) rats. Hypoxia inducible factor-2, a master regulator of erythropoiesis and iron metabolism, has been reported to be activated by Sirtuin 1, but oral supplementation of resveratrol, an activator of Sirtuin 1, failed to improve anemia in DS rats. Oral supplementation of folic acid and parenteral supplementation of iron also failed to improve anemia in DS rats. Orally administrated Juzen-taiho-to, Chinese herbal medicine, ameliorates anemia in DS rats. As a mechanism of anemia, we found that reduced half-life of red blood cells is a major factor of anemia. These findings may facilitate the development of new strategy for treating anemia and iron deficiency in CHF.
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| Free Research Field |
循環器内科学
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