The roles of macrophage polarization in vascular remodeling

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591109
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: TAKEDA NORIHIKO 東京大学, 医学部附属病院, 特任講師 (40422307)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 炎症 / 低酸素シグナル / 血管リモデリング

Outline of Final Research Achievements

Vascular remodeling develops during the pathogenesis of atherisclerosis, aortic aneurysm and tumor progression. While the vascular integrity critically influence the progression of these disorders, its underlying mechanisms are still unclear.
Macrophages are key mediators of inflammation, and can be broadly classified as M1 (pro-inflammatory) and M2 (anti-inflammatory) type. In this study, we examined the molecular link how macrophage poralization affect the vascular remodeling processes, and elucidated that persistent accumulation of pro-inflammatory macrophages elicits the immature vessel formation. These results showed that not only regulating the abundance of angiogenic factor, but also modulating the behavior of inflammatory cells could be a potential therapeutic target in normalization of the vascular remodeling processes.

Free Research Field

循環器内科学