2014 Fiscal Year Final Research Report
Molecular mechanisms of vascular inflammation induced by uremic toxins
| Project/Area Number |
24591111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YOSHIDA Masayuki 東京医科歯科大学, 生命倫理研究センター, 教授 (80282771)
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| Co-Investigator(Kenkyū-buntansha) |
OSAKA Mizuko 東京医科歯科大学, 生命倫理研究センター, 助教 (00581711)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 血管内皮細胞 / 炎症反応 / 心腎連関 |
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| Outline of Final Research Achievements |
Indoxyl sulfate, a member of uremic toxins, significantly induces Ly6C-high monocytes recruitment to cuff-injured mouse femoral artery. These monocytes strongly express CCR2, suggesting a role forMCP-1 and CCR2 dependent signaling. Endothelial specific knock out mouse of AhR, a receptor of indoxyl sulfate, failed to exhibit indoxyl sulfate-induced monocyte recruitment.
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| Free Research Field |
循環器病学、血管細胞生物学
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