Role of adiponectin in COPD

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591129
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Osaka University
• Principal Investigator: TAKEDA Yoshito 大阪大学, 医学(系)研究科(研究院), 助教 (40452388)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アディポネクチン / COPD / CT / 超編極ガスXe-MRI

Outline of Final Research Achievements

COPD is predicted to become the third commonest cause of death worldwide by 2020. It is important to clarify mechanisms involved in COPD and explore drugs to treat this systemic disease. Given that hypoadiponectinemia could be an underlying mechanism for COPD and the key link between COPD and various comorbidities, to further test the phenotype of APN KO mice, examined its underlying mechanism and its potential use of therapy is significant. Using mouse model, we evaluated the availability of hyperpolarized 129Xe MRI and micro- CT compared with traditional methods, such as plethysmography and histology in murine model.

Free Research Field

呼吸器内科