Role of sphingolipids in the respiratory immune system

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591131
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kobe University
• Principal Investigator: NISHIMURA Yoshihiro 神戸大学, 医学部附属病院, 教授 (20291453)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Kazuyuki 神戸大学, 大学院医学研究科, 講師 (50403275) ; OKADA Taro 神戸大学, 大学院医学研究科, 准教授 (80304088)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: スフィンゴシン1リン酸 / スフィンゴシン1リン酸受容体 / 喘息 / JTE013 / TSLP / IL-25 / IL-33

Outline of Final Research Achievements

Sphingosine kinase phosphorylates sphingosine to generate sphingosine 1 phosphate (S1P). S1P stimulates the five S1P receptors (S1PR), but S1PRs’ roles in the respiratory system and the therapeutic effect of S1PR antagonist in experimental asthma mouse model are not well understood. Bronchial epithelial cells in mouse lung expressed S1PR1 to 3. S1P induced proinflammatory cytokine production by the bronchial epithelial cells. In experimental asthma model, JTE013 exhibited substantially attenuated eosinophilic inflammation. In conclusion, JTE013 attenuated eosinophilic inflammation via regulating proinflammatory cytokines from bronchial epithelial cells. Our results suggest that JTE013 might be a possible candidate for the bronchial asthma treatment.

Free Research Field

医歯薬学