2015 Fiscal Year Final Research Report
Novel strategy of nutritional intervention for preventing progress and onset of COPD
| Project/Area Number |
24591133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Hiroshi 奈良県立医科大学, 医学部, 教授 (20195374)
TOMODA Koichi 奈良県立医科大学, 医学部, 准教授 (90364059)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 慢性閉塞性肺疾患 / 栄養療法 / 腸内環境 / 食生活 / シンバイオティクス |
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| Outline of Final Research Achievements |
Gut-lung axis may play a role in the development of chronic obstructive pulmonary disease (COPD) and it is assumed that the deterioration in gut environment is associated with the development of comorbidities of COPD. In the present study, we found that the deterioration in gut environment caused by discontinuous feeding with fiber-free diet accelerates not only emphysema but also malnutrition and osteoporosis by cigarette smoke in rats. In addition, it suggests that the changes in the gut environment by the synbiotics may attenuate not only pulmonary emphysema but also osteoporosis induced by cigarette smoke in rats. Feasibility of the synbiotics was confirmed and the intervention study in patients with COPD is ongoing.
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| Free Research Field |
呼吸器内科学
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