2014 Fiscal Year Final Research Report
Studies on pathoetiology of chronic obstructive pulmonary disease
| Project/Area Number |
24591140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | COPD / DNA障害 / 細胞老化 / 肺気腫 / 慢性炎症 / 肺癌 / 進化医学 |
|---|
| Outline of Final Research Achievements |
We studied the pathoetiology of COPD and obtained the following results: 1) In the lungs of COPD patients, chronic DNA damage contributes to cell senescence, apoptosis, chronic inflammation and tumorigenesis; 2) In mice exposed to cigarette smoke, oxidative damage occurs in the heart and adipose tissue as well as the lungs; 3) In mice repeatedly exposed to bromodeoxyuridine, chronic DNA damage causes persistent lung inflammation; 4) In mice repeatedly exposed to naphthalene, airway fibrosis occurs due to chronic airway epithelial injury; 5) In mice exposed to bleomycin, DNA damage in the lungs causes chronic lung inflammation; 6) Based on the above results, we proposed an evolutionary medicine approach to understand factors that contribute to the development of COPD.
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| Free Research Field |
COPD
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