2014 Fiscal Year Final Research Report
Analyses of Nampt gene mutation and its function to establish new target of lung cancer treatment.
| Project/Area Number |
24591147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKUMURA Shunsuke 旭川医科大学, 医学部, 特任助教 (10516339)
SASAKI Takaaki 旭川医科大学, 医学部, 助教 (70516997)
MINAMI Yoshinori 旭川医科大学, 大学病院, 医員 (10545445)
ENDO Satoshi 旭川医科大学, 医学部, 助教 (00545444)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 呼吸器学 / 肺癌 / 腫瘍学 / 分子標的薬 / 抗癌剤 |
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| Outline of Final Research Achievements |
Nampt inhibitor showed strong inhibitory cell growth effect against lung cancer culture cell lines with KRAS gene mutation. Analyses of cell growth signaling revealed that MAPK・PI3K/AKT signaling path way was not affected by Nampt inhibitor.
Thses findings were presented at AACR meeting in 2015.
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| Free Research Field |
呼吸器学
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