Basic study of IgG4-related respiratory disease using the model mouse

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591158
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: University of Toyama
• Principal Investigator: MATSUI Shoko 富山大学, 保健管理センター, 准教授 (40334726)
• Co-Investigator(Kenkyū-buntansha): KAWANO Mitsuhiro 金沢大学, 大学病院, 講師 (20361983) ; HAYASHI Ryuji 富山大学, 大学病院, 講師 (60345585) ; YAMADA Kazunori 金沢大学, 医薬保健学総合研究科, 特任准教授 (90397224)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: IgG4関連疾患 / IgG4関連呼吸器疾患

Outline of Final Research Achievements

LATY136F Knock-in mice (LAT mice), having a mutation in Tyr136 of the linker for activation of T cells, show accumulation of Th2 effector cells. IgG4-related disease (IgG4-RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4 positive plasma cells. We examined lung lesion of LAT mice whether they became the model of IgG4-RD. Lung fibrosis score were significantly higher in Homo group than in Wild group and there were tissue infiltration by lymphocytes and IgG1 positive plasma cells around broncho-vascular bundles. In analysis of bronchoalveolar lavage, total cell count and percentage of lymphocyte increased in Homo group. The feature of lung lesion of LAT mice has a similar with them of IgG4-RD. We considered that they could be a model of IgG4-RD.

Free Research Field

呼吸器内科