Anti-fibrotic function of Surfactant Protein-D in bleomycin induced lung fibrosis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591167
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: AONO Yoshinori 徳島大学, ヘルスバイオサイエンス研究部, 非常勤講師 (50398004)
• Co-Investigator(Kenkyū-buntansha): GOTO Hisatsugu 徳島大学, 大学院ヘルスバイオサイエンス研究部, 講師 (00437641)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: SP-D / 増殖因子 / 肺線維症 / fibrocyte / マクロファージ

Outline of Final Research Achievements

Serum SP-D concentration is an important biomarker in patients with idiopathic pulmonary fibrosis, but its role in lung fibrosis is unknown. We examined the role of SP-D in bleomycin (BLM) induced pulmonary fibrosis model using SP-D conditional mice. BLM-treated SP-D off mice had increased lung fibrois compared to SP-D on mice. SP-D deficiency also increased macrophage and fibrocyte-dominant cell infiltration and the expression of growth factors (TGF-beta, PDGF) from the cells in the lung of BLM treated mice. These data suggest that alveolar SP-D regulates numbers of macrophages and fibrocytes in the lungs, growth factor expression, and fibrotic lung remodeling in response to BLM injury

Free Research Field

呼吸器