2014 Fiscal Year Final Research Report
Role of prolactin receptor in kidney glomerular podocyte
| Project/Area Number |
24591191
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NARITA Ichiei 新潟大学, 医歯学系, 教授 (20272817)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | プロラクチン / プロラクチン受容体 / 糸球体上皮細胞 |
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| Outline of Final Research Achievements |
Prolactin receptor has been reported to be expressed in kidney tubular cells and to be associated with natriuresis, but its expression in kidney glomerular podocyte was not known. In order to clarify the role of prolactin receptor in glomerular podocyte, we generated transgenic mice in which human prolactin receptor was expressed in glomerular podocyte specifically. We verified that human prolactin receptor was expressed in glomerular podocyte in transgenic mice, but the phenotypic difference with wild type mice was not observed in the condition of hyperprolactinemia, and further investigation should be continued.
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| Free Research Field |
腎臓内科学
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