2014 Fiscal Year Final Research Report
Generation of erythropoietin-producing cells derived from human iPSCs
| Project/Area Number |
24591204
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 再生医学 / 移植・再生医療 / iPS細胞 / エリスロポエチン / 腎性貧血 |
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| Outline of Final Research Achievements |
We established a method to generate erythropoietin (EPO)-producing cells from human induced pluripotent stem cells (hiPSCs) that showed increased EPO expression and secretion in response to low oxygen conditions. The EPO protein secreted from hiPSC-derived EPO-producing cells (hiPSC-EPO cells) induced the erythropoietic differentiation of umbilical cord blood progenitors in vitro. Furthermore, injection of EPO protein from hiPSC-EPO cells improved renal anemia in adenine-induced renal failure mice. In conclusion, hiPSC-EPO cells may provide a novel therapeutic agent for anemia.
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| Free Research Field |
腎臓内科学、再生医学、薬理学
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