2014 Fiscal Year Final Research Report
Systematic identification of serine proteases involved in the progression of CKD
| Project/Area Number |
24591206
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
|
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| Research Institution | University of Yamanashi (2014)
Kumamoto University (2012-2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 慢性腎不全 / セリンプロテアーゼ |
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| Outline of Final Research Achievements |
Few therapeutic strategies have been established for the treatment of chronic kidney diseases (CKD). Therefore, to develop a new class of the drugs is absolutely required for the patients with CKD to avoid the renal replacement therapy. Here, we demonstrated that a serine protease inhibitor significantly reduced the progression of CKD by ameliorating the glomerulosclerosis and by inhibiting the interstitial fibrosis, which suggests that serine proteases are involved in the development of the progression of CKD. In addition, we isolated plasmin as a candidate serine protease involved in the aldosterone induced renal injury.
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| Free Research Field |
腎臓内科学
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