2015 Fiscal Year Final Research Report
The effects of mineral metabolism on the progression of DM nephropathy
| Project/Area Number |
24591215
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
URASHIMA Mituyoshi 東京慈恵会医科大学, 分子疫学研究部, 教授 (80203602)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | ビタミンD / FGF23 / リン / 糖尿病 / インスリン抵抗性 |
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| Outline of Final Research Achievements |
We evaluated the association between factors concerning mineral metabolism and those concerning diabetes by using cohorts of HD patients (1280 cases) and DM patients (408 cases). We found the influences of vitamin D on the progression of DM nephropathy and also found the effects of SNP（FokⅠVDR）and Copy Number Variation （CNV；UGT2B17）on the progression of DM nephropathy.Serum levels of FGF23, which suppress vitamin D activation showed a positive correlation with resistin concerning insulin resistance.
Depending on our results, we hypothesize that mineral metabolism effects the progression of DM nephropathy.
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| Free Research Field |
医歯薬学
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