Development of functional redox nanoparticle for long-term peritoneal dialysis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591224
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Tsukuba University of Technology
• Principal Investigator: AKI HIRAYAMA 筑波技術大学, 保健科学部, 教授 (20323298)
• Co-Investigator(Kenkyū-buntansha): YOSHITOMI Toru 筑波大学, 数理物質科学研究科(系), 研究員 (20585799) ; NAGASAKI Yukio 筑波大学, 数理物質科学研究科(系), 教授 (90198309)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ナノメディシン / 酸化ストレス / 腹膜透析 / 慢性腎臓病

Outline of Final Research Achievements

Encapsulating peritoneal sclerosis (EPS) is a major cause that prevent long-term peritoneal dialysis leading to a loss of quality of life in patients. In this study, we developed bionanoparticle which prevented peritoneal inflammation by its internal antioxidant and enhanced absorption of low molecular-weight uremic toxins by its contained silica. The developed nanoparticle: silica-contained redox nanoparticle (SiRNP), effectively suppressed the peritoneal thickness in EPS model when it was contained to peritoneal dialysate. In addition, SiRNP decreased blood urea nitrogen and serum creatinine levels in renal failure model.

Free Research Field

腎臓内科学，人工透析学，酸化ストレス医学