The role of megalin in secondary hyerparathyroidism of uremia

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591235
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Osaka City University
• Principal Investigator: IMANISHI Yasuo 大阪市立大学, 医学(系)研究科(研究院), 講師 (50326253)
• Co-Investigator(Kenkyū-buntansha): YAMAGATA Masayo 大阪大谷大学, 薬学部, 講師 (50454583)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 副甲状腺メガリン

Outline of Final Research Achievements

Megalin is a multiligand endocytotic receptor involving in the reabsorption of calcitriol and vitamin D binding protein in renal proximal tubules. Parathyroid glands also express megalin, however, little is known about its expressions and pathophysiological roles in hyperfunctioning parathyroid tumors. Its expression was observed in plasma membranes and cytoplasm in normal parathyroid glands. The expressions decreased in tumors with primary hyperparathyroidism and secondary hyperparathyroidism of uremia (SHPT) compared with strong expression in normal parathyroid glands. In SHPT, its expression was often particularly depressed in nodular areas, compared with adjacent diffuse hyperplasias. The reduced expression of both megalin and VDR may enhance vitamin D resistance and hyper-secretion of PTH from these tumors.

Free Research Field

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