2014 Fiscal Year Final Research Report
Removal of albumin-bound toxin and albumin refolding by electrical dialysis and artificial chaperon
| Project/Area Number |
24591238
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
KOKUBO Kenichi 北里大学, 医療衛生学部, 准教授 (20287965)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Hirosuke 北里大学, 医療衛生部, 教授 (70153632)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | アルブミン結合毒素 / 効率的除去 / インドキシル硫酸 / リフォールディング |
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| Outline of Final Research Achievements |
The aim of the present study was to develop a method to effectively remove protein bound toxins by unbinding toxin from protein using denaturant and by refolding the protein. Using urea as a denaturant, protein bound toxins effectively removed. The protein can be refold by rapidly removing urea by the modified apparatus for dialysis.
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| Free Research Field |
臨床工学
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