2014 Fiscal Year Final Research Report
Role of KLF4 on phosphate-induced vascular calcification and cardiovascular diseases
| Project/Area Number |
24591239
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
HAYASHI Matsuhiko
YAMASHITA Maho
HORIMAI Chihiro
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 血管石灰化 / 動脈硬化 / 慢性腎臓病 / 心肥大 |
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| Outline of Final Research Achievements |
Vascular calcification is frequently seen in patients with end-stage kidney disease. Clarification of the mechanisms for vascular calcification is of significant importance, because it is closely related to the mortality in these patients. We studied the molecular mechanisms of vascular calcification in renal disease. We found that KLF4, a transcription factor, contributed to high phosphate-induced phenotypic switching of vascular smooth muscle cells into osteogenic cells, thereby affecting vascular calcification. We also found that KLF4 interacted with NF-kB, a critical factor for inflammation, and that KLF4 was involved in the formation of atherosclerosis and cardiac hypertrophy.
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| Free Research Field |
心腎血管疾患
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