2014 Fiscal Year Final Research Report
Roles of hydrogen peroxide-inducible clone-5 on vascular disease in chronic kidney disease
| Project/Area Number |
24591241
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AKIRA Miyazaki 昭和大学, 医学部生化学教室, 教授 (70253721)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 細胞接着斑蛋白質 / 血管石灰化 / 動脈硬化 / 慢性腎臓病 |
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| Outline of Final Research Achievements |
Chronic kidney disease (CKD) is a risk factor for cardiovascular disease. Purpose of the study was to assess roles of hydrogen peroxide-inducible clone-5 (HIC-5) on vascular disease in CKD.
Expressions of HIC -5 were increased at vascular smooth muscles cells (VSMC) and on endothelial lesions of carotid arteries at autopsy samples from patients with CKD. HIC-5 was over expressed in process of VSMC calcification in cell culture with phosphate overload and was associated with interaction between macrophages and vascular endothelial cells in vitro model. Moreover, HIC-5 was associated with development and progression of atherosclerotic lesions of animal model.
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| Free Research Field |
腎臓病学
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