2014 Fiscal Year Final Research Report
The regulation of autophagy and the development of polycystic kidneys by an intracellulat aquaporin
| Project/Area Number |
24591243
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
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| Research Collaborator |
TANAKA Yasuko 明治薬科大学, 病態生理学, 講師 (20386452)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 水チャネル / オートファジー / 腎のう胞 / 小胞体ストレス / 細胞内空胞 / 近位尿細管 / ノックアウトマウス / トランスジェニックマウス |
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| Outline of Final Research Achievements |
The aquaporin-11 (AQP11) is a water channel expressed at the intracellular organelle. The AQP11 null mice are fatal due to kidney failure caused by polycystic kidneys around one month after birth. Before developing polycystic kidneys, their proximal tubular cells have multiple vesicles. We have identified enhanced autophagy, a self-degradative process in the proximal tubules of AQP11 null mice as well as their primary cultured cells with visualization of activated LC3, a marker for autophagy. Our results suggest that the manipulation of autophagy will be a promising treatment modality for polycystic kidneys.
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| Free Research Field |
水・電解質代謝
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