Elucidation of novel autoantibodies against axo-glial junctions in chronic inflammatory demyelinating radiculopolyneuropathy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591265
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyushu University
• Principal Investigator: NOBUTOSHI Kawamura 九州大学, 医学(系)研究科(研究院), 研究員 (00432930)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Satoshi 九州大学, 大学病院, 助教 (20596390) ; MATSUSE Dai 九州大学, 大学病院, 助教 (70596395)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 神経免疫 / 自己抗体 / 慢性炎症性脱髄性多発根ニューロパチー / ランビエ絞輪

Outline of Final Research Achievements

In this study, we clarified that 18% of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) were positive for antibodies against neurofascin 155 (NF155), which is cell-adhesion molecule and located around nodes of Ranvier. The anti-NF155 antibody-positive CIDP patients had significantly younger onset age, more frequent occurrence of distal acquired demyelinating symmetric phenotype and tremor, longer distal and F wave latencies, greater cerebrospinal fluid protein levels, and greater cervical root diameters than anti-NF155 antibody-negative CIDP patients. Marked symmetric hypertrophy of cervical and lumbosacral roots/plexuses was present in all the anti-NF155 antibody-positive CIDP patients examined by MRI neurography. A part of the anti-NF155 antibody-positive CIDP patients also had demyelination in the central nervous system, which suggested that this autoantibody could induce combined central and peripheral demyelination.

Free Research Field

神経免疫学