2014 Fiscal Year Final Research Report
Establishment of HTLV-1 infection model via dendritic cells and the use to screening of medicines.
| Project/Area Number |
24591280
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Masakazu 関西医科大学, 医学部, 助教 (20454613)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | HTLV-1 / 感染モデル / 樹状細胞 |
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| Outline of Final Research Achievements |
In HTLV-1 associated myelopathy (HAM), the infection model that is useful for screening of the medicine does not exist. Therefore, in this study, we tried to establish HTLV-1 infection model and be intended to use it for the screening of therapeutic drugs of HAM. At first, we manufactured a virus reservoir by transducing a virus expression vector to differentiation dendritic cells. Then, we established a rating system of the viral infection to a target cell by making a new index cell. It was confirmed that efficiency of the viral infection decreased by adding a blocking antibody in this system. Because it was thought that HTLV-1 infection model to the T cell via the dendritic cell was established, we will apply this system to the screening of drugs in further study.
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| Free Research Field |
神経内科学、神経ウイルス学
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