Correlation of Cinicoserologic and Pathologic Features of Inflammatory Myopathies

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591289
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: The University of Tokyo
• Principal Investigator: SHIMIZU Jun 東京大学, 医学部附属病院, 講師 (40260492)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: inflammatory myopathies / autoantibodies / histology

Outline of Final Research Achievements

The purpose of the project was to elucidate the correlation among clinical and histological features and autoantibodies in idiopathic inflammatory myopathies (IIMs). I found that patients with IIM associated with anti-mitochondrial antibody frequently have chronic disease course with cardio-pulmonary involvement showing granulomatous inflammation in histopathological findings. I found that patients with serum anti-Tif1γ antibody have close temporal association with cancer and frequently show C5b-9 deposition with perifascicular atrophy as a histological finding. I also found that perifascicular atrophy is a histopathological finding with frequent association with serum anti-Tif1γ, Jo1, or Mi-2 antibodies, which suggested the heterogeneous back ground of dermatomyositis. The above findings suggested that clinic-serological and pathological approach is important not only for classification of IIMs but also for revealing pathological mechanisms of IIMs.

Free Research Field

神経内科　炎症性筋疾患　免疫性神経疾患