2014 Fiscal Year Final Research Report
The spectrum of pathological involvement of enteric nervous system in synucleinopathy
| Project/Area Number |
24591290
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIZAWA Masatoyo 新潟大学, 脳研究所, 教授 (80198457)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | シヌクレイノパチー / 多系統萎縮症 / 消化管神経叢 / 腸管ニューロン / 神経変性 / 自律神経 / 消化器症状 |
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| Outline of Final Research Achievements |
Patients with synucleinopathies including multiple system atrophy (MSA) frequently exhibit gastrointestinal symptoms. This study aimed to determine whether enteric neurons in MSA patients are involved in the pathogenic mechanism of MSA. Serial 4 μm-thick slices of the small intestine were prepared using 10%-formalin fixed and paraffin embedded materials from 3 autopsied cases of MSA. A quantitative assessment of cross-sectional areas of enteric neurons having nuclei was performed using the computer software (cellSens ver. 1.6). In myenteric neurons, mean cross-sectional areas of cytoplasm and nuclei were 115.9±4.8 μm2 and 50.0±1.6 μm2, respectively. These areas of cytoplasm and nuclei were significantly smaller in MSA than in age-matched controls (P<0.0001). In submucosal neurons, there was no significant difference in these areas between MSA and control.
Our results suggest atrophic changes in myenteric neurons, which contribute to the gastrointestinal symptoms in MSA patients.
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| Free Research Field |
医歯学系
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