Efficacy of cholinesterase inhibitor drugs in early Parkinson's disease patients

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591293
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Nagoya University
• Principal Investigator: WATANABE hirohisa 名古屋大学, 脳とこころの研究センター, 特任教授 (10378177)
• Co-Investigator(Kenkyū-buntansha): ITO Mizuki 名古屋大学, 医学部附属病院, 助教 (50437042) ; SENDA Joe 名古屋大学, 医学部附属病院, 医員 (80569781) ; NAKAMURA Tomohiko 名古屋大学, 医学部附属病院, 助教 (00437039) ; HIRAYAMA Masaaki 名古屋大学, 医学系研究科, 准教授 (30283435) ; SOBUE Gen 名古屋大学, 医学系研究科, 教授 (20148315)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: パーキンソン病 / 精神症状 / 神経画像 / MRI

Outline of Final Research Achievements

In Parkinson's disease with visual hallucination (The PD-VH) patients, they showed significant cortical atrophy compared to the PD patients without visual hallucination in the frontal lobe (bilateral dorsolateral prefrontal cortex, left rostral region of the prefrontal cortex, left ventral section of the cingulate cortex), occipital and parietal cortex (bilateral primary visual cortex, and secondary visual cortex including the left inferior occipital gyrus, right lingual cortex, right supramarginal gyrus, and left fusiform gyrus). Significant subcortical atrophic changes were observed in the white matter of the right parahippocampal gyrus, the bilateral posterior part of the cingulate gyrus, the left lingual gyrus, and the right middle occipital gyrus. Visual hallucination in PD can occur due to distinctive neuroanatomical involvement. We also demonstrated that patients with severe olfactory dysfunction showed significant involvement of amygdala, substantia nigra, and insular network.

Free Research Field

神経内科学