Neuroaxonal dystrophy and mitochondrial injury in dopaminergic neurons of PLAN.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591295
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Osaka University
• Principal Investigator: SUMI-AKAMARU Hisae 大阪大学, 医学(系)研究科(研究院), 助教 (30403059)
• Co-Investigator(Kenkyū-buntansha): BECK Goichi 大阪大学, 大学院医学系研究科, 医員 (20626353)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: PLA2G6 / ミトコンドリア / αシヌクレイン / レヴィ小体 / 家族性パーキンソン病

Outline of Final Research Achievements

We previously found that injured mitochondria in motoneurons occur neuroaxonal dystrophy in PLA2G6 knockout mice, which is an excellent model of familial parkinsondisease (PARK14).In this research, we demonstrated neuroaxonal dystrophy occurs also in dopaminergic neurons of PLA2G6 knockout mice. More, endogenous alpha-synuclein accumulated to injured mitochondria of motoneurons in PLA2G6 knockout mice. In patient’s brain, lewy bodies contained much component of mitochondrial membranes. These suggests that the mitochondrial membranes would be associated with alpha-synucleinopathy.

Free Research Field

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