Basic research to establish novel therapy for Parkinson disease using neuromodulation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591304
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Juntendo University
• Principal Investigator: SHIMO Yasushi 順天堂大学, 医学部, 准教授 (70286714)
• Co-Investigator(Kenkyū-buntansha): OYAMA Genko 順天堂大学, 医学部, 准教授 (00407256) ; YOSHIMI Kenji 順天堂大学, 医学部, 准教授 (40459136) ; HATTORI Nobutaka 順天堂大学, 医学部, 教授 (80218510)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: パーキンソン病 / 脳深部刺激療法 / 大脳基底核

Outline of Final Research Achievements

High-frequency electrical stimulation of the subthalamic nucleus (STN) and internal segment of the globus pallidus (GPi) is a therapeutic option for human movement disorders however,the precise mechanisms are still unknown.
To elucidate this point, neuronal activity of the interneurons in the putamen (TANs) was extracellularly recorded during the electrical stimulations of STN and GPi using three normal monkeys. Many TANs reduced their activity during STN and GPi stimulations. 36% of neurons inhibitory during STN stimulation were diminished after local injection of sulpiride. 25% of neurons showed diminishing inhibitory response during GPi stimulation with GABA-B antagonist injection. Our results indicate that electrical stimulations of STN and GPi modulate cholinergic tone in the striatum. Furthermore, we hypothesize that dopamine and GABA play important roles in the therapeutic mechanisms of STN and GPi deep brain stimulations (DBS) in humans.

Free Research Field

神経内科