Morphological analysis of the entorhino-hippocampal reinnervation participates in the spontaneous recovery after unilateral lesion of the entorhinal cortex.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591305
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: HONDA Yoshiko 東京女子医科大学, 医学部, 准教授 (40287313)
• Co-Investigator(Renkei-kenkyūsha): SHIBATA Hideshi 東京農工大学, 大学院農学研究院 動物生命化学部門 獣医解剖学研究室, 教授 (50145190)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 記憶 / 海馬 / 歯状回 / 嗅内野 / 神経再支配

Outline of Final Research Achievements

Projections from the entorhinal cortex (EC) to the hippocampal formation are known as the principal part of the memory circuit. It is also known that unilateral lesion of EC results in the significantly increased innervation (reinnervation) of the dentate gyrus (DG) from contralateral side of EC, suggesting spontaneous recovery of memory impairment. We aim to clarify the mechanism of morphological changes of single EC neurons in such phenomenon, by comparing to the normal pattern of axonal collateralization. Our study revealed that the distribution of hippocampal projection neurons in normal EC showed a band-like pattern with topographic organization, and also found that layer V neurons in normal EC formed complex terminal arborization in DG. We also investigated the efficient procedure for making experimental model of reinnervation and further experiments are in progress in order to collect enough data for analysis.

Free Research Field

神経解剖学