2014 Fiscal Year Final Research Report
Development of biomarker of Parkinson disease using Neuroimaging
| Project/Area Number |
24591306
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 神経内科学 / 神経機能画像学 / 機能的MRI |
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| Outline of Final Research Achievements |
The goal of this study is to establish the biomarker of PD by comparing the BGTM connectivity between control, PD and Atypical Parkinsonism (AP). PD patients, AP patients and age-matched control subjects performed a protocol involving finger movements, while being scanned with functional magnetic resonance imaging. Analysis using structural equation modeling (SEM) exhibited reduced connectivity from the thalamus to the motor cortices in AP and PD patients compared with control group, while there was disturbed connectivity within the lentiform nucleus only in the AP group. These results suggest the utility of SEM for biomarker of PD.
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| Free Research Field |
内科系臨床医学
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