Chronic monitoring of cortical activity using telemetry systems of capsule endoscopy and subdural electrodes in freely moving animals

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591308
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Soka University (2015); Tokyo Metropolitan Institute of Medical Science (2012-2014)
• Principal Investigator: Masahito Nemoto 創価大学, 公私立大学の部局等, 研究員 (80370980)
• Co-Investigator(Kenkyū-buntansha): KOGURE SHINICHI 創価大学, 理工学部, 教授 (10133448) ; KAWAI HIDEKI 創価大学, 理工学部, 教授 (90546243)
• Co-Investigator(Renkei-kenkyūsha): HOSHI YOKO 浜松医科大学, メディカルフォトニクス研究センター, 教授 (50332383) ; SEIYAMA AKITOSHI 京都大学, 医学研究科, 教授 (70206605)
• Research Collaborator: HARIMA YUKI 創価大学, 理工学部
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 神経活動・脳循環カップリング / 内因性光学信号 / 脳機能マッピング / 神経可塑性

Outline of Final Research Achievements

The purpose of this study is monitoring of cortical activity using telemetry systems of capsule endoscopy and subdural electrodes in freely moving animals. There are problems with capsule endoscopy which images local cortical activity by detecting changes in cerebral blood volume and oxygenation, such as image quality, color filter array for imaging sensor, wavelength of LED light source, automated control of illumination intensity, and replacing method of battery. To solve these problems, we employed a wearable camera, GoPro Hero 4 black edition, instead of capsule endoscopy. The wearable cameras are not implantable but can be mounted on the back of animal (rat) jacket. The camera can image cortical activity, which is joined to fiberscope with side view mirror on cranial window.

Free Research Field

神経生理学　脳循環代謝学　脳神経外科学