Elucidation of mechanism by which FSP27 regulates insulin sensitivity by modulating fat distribution among each organ.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591331
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kobe University
• Principal Investigator: TAMORI YOSHIKAZU 神戸大学, 医学(系)研究科(研究院), 教授 (90379397)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脂肪細胞 / 肥満 / インスリン抵抗性

Outline of Final Research Achievements

FSP27 plays an important role in the efficient lipid storage in adipocytes. Expression level of FSP27 in white adipocytes reflects the ability of lipid storage in adipocytes. Excessive nutrition for a long time deteriorates hepatic steatosis and insulin resistance of FSP27 knockout mice more than control mice despite smaller adipose tissue and adipocyte size in the knockout mice. This implies that the ability of lipid storage in adipocytes is essential for the maintenance of the systemic insulin sensitivity by regulating the hepatic lipid storage independently of the adipocyte size.

Free Research Field

内科系臨床医学・代謝学