2014 Fiscal Year Final Research Report
Molecular mechanism for the beneficial effect of exercise on glucose and lipid metabolism, and search for exercise mimetics
| Project/Area Number |
24591332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 運動による代謝改善作用 / 運動効果模倣薬 |
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| Outline of Final Research Achievements |
We identified novel transcriptional coactivators, PGC1αb/c, whose expression in skeletal muscle were markedly upregulated by exercise. The study of PGC1αb/c knockout mice demonstrated that these transcriptional coactivators mediate the beneficial effect of exercise on glucose and lipid metabolism, suggesting that PGC1αb/c could be a novel therapeutic targets for metabolic disease. In this study, we searched the compounds which increase the expression of PGC1αb/c in muscle cells. We also identified transcription factor X interacted with PGC1αb/c in skeletal muscle and generated skeletal muscle-specific knockout mice of transcription factor X. The analysis of these knockout mice will reveal the precise mechanism for metabolic regulation.
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| Free Research Field |
代謝学
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