2014 Fiscal Year Final Research Report
The strategy for elucidation of diabetogenic factors:functional partition and reintegrate
Project/Area Number |
24591346
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
|
Research Institution | Kinki University |
Principal Investigator |
BABAYA Naru 近畿大学, 医学部, 講師 (10449837)
|
Co-Investigator(Kenkyū-buntansha) |
IKEGAMI Hiroshi 近畿大学, 医学部, 教授 (20221062)
KAWABATA Yumiko 近畿大学, 医学部, 准教授 (80423185)
NOSO Shinsuke 近畿大学, 医学部, 講師 (90460849)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 糖尿病疾患感受性遺伝子 |
Outline of Final Research Achievements |
Type 2 diabetes are multifactorial diseases caused by a complex interaction of environmental and genetic factors, with the latter consisting of multiple susceptibility genes, making it difficult to clarify their functions and interactions in conferring susceptibility to type 2 diabetes in humans. In this study, we constructed consomic and congenic strains, in which the NSY-derived diabetogenic region was introgressed onto the genetic background of control mice. We succeeded to localize and characterize the function of diabetogenic region in the NSY.
|
Free Research Field |
糖尿病
|