Bone metabolism and its disruption in pH receptor knockout mice

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591349
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Gunma University
• Principal Investigator: MOGI Chihiro 群馬大学, 生体調節研究所, 助教 (00375528)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: pH / Gタンパク質共役型受容体 / 破骨細胞

Outline of Final Research Achievements

It is well known that extracellular pH plays important roles in bone metabolism, but the molecular mechanisms are yet unidentified. To reveal the roles of novel four proton-sensing receptors (OGR1, GPR4, TDAG8, G2A) in bone remodeling, we generated osteoclasts and osteoblasts from bone marrow cells from pH-receptor knockout mice. These results indicate the relationship between OGR1 family and bone metabolism. We also assessed rheumatoid arthritis as in vivo model for studying acidification by accumulation of inflammatory cells.

Free Research Field

細胞生物学