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2014 Fiscal Year Final Research Report

Network of microRNA in pituitary adenomas

Research Project

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Project/Area Number 24591365
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Endocrinology
Research InstitutionThe University of Tokushima

Principal Investigator

YOSHIMOTO Katsuhiko  徳島大学, ヘルスバイオサイエンス研究部, 教授 (90201863)

Co-Investigator(Kenkyū-buntansha) IWATA Takeo  徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (10350399)
MIZUSAWA Noriko  徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (80254746)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords下垂体 / 腫瘍化 / microRNA / ACTH産生腺腫
Outline of Final Research Achievements

Transfection of miR-551b, which were underexpressed in human ACTH-producing pituitary adenomas, was found to suppress cell growth of AtT-20 cells, a cell line of mouse ACTH-producing tumors.
We found several human ACTH-producing adenomas in which high expression of ERBB4 mRNA, one of target candidate genes of miR-551b, were observed. We confirmed that ERBB4 mRNA was a target of miR-551b by co-tranfection of miR-551b and a reporter plasmid including luciferase-ERBB4 3'-untranslated region in HEK293 cells. Positive correlation between low expression of miR-551b and methylation status of CpG islands in the possible promoter of miR-551b gene was not found.

Free Research Field

内分泌学

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Published: 2016-06-03  

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