2014 Fiscal Year Final Research Report
Clarification of parathyroid cell differentiation, oriented for the cell therapy of osteoporosis
| Project/Area Number |
24591366
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 副甲状腺ホルモン / カルシウム代謝 / 骨粗鬆症 |
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| Outline of Final Research Achievements |
1.Parathyroid hormone (PTH) gene expression is inhibited by hypercalcemia, involving CaSR, NFAT, and Sp1/Sp6. 2. hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is caused by GATA3 haploinsufficiency, and novel GATA3 mutation (R299Q) was identified. Decreased GATA3 activity causes decrease in GCM2 expression, with resultant defect in parathyroid development and PTH deficiency. 3. A variety of GCM2 gene mutation also causes congenital hypoparathyroidism.
Altogether, transcription factors GATA3, GCM2, and Sp1/Sp6 are supposed to be critical for the development and normal regulation of parathyroid gland, including PTH gene expression.
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| Free Research Field |
内分泌・代謝病学
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