2014 Fiscal Year Final Research Report
Elucidation of the role of molecular motor proteins in the mechanism of action of steroid hormone receptor
| Project/Area Number |
24591367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAYANAGI Ryoichi 九州大学, 大学院医学研究院, 教授 (30154917)
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| Research Collaborator |
HORIUCHI Toshihiro
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ステロイドホルモン / 核内受容体 |
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| Outline of Final Research Achievements |
1. Molecular motor protein myosins (myosin V, VI, VIII) and dynein were fused with fluorescent GFP proteins and intracellular localization of these fusion proteins were examined. However, colocalization of these molecular motor proteins with steroid hormone receptors has not been observed.
2. A new SERM, bazedoxifene, did not cause translocation of estrogen receptors into the nucleoli, which was observed after treatment with raloxifene. However, bazedoxifene markedly suppressed ER-mediated transcriptional activation as well as raloxifene.
3. It has been suggested that TXNIP is involved in the process of acquisition of glucocortocoid-induced insulin resistance in preadipocytes.
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| Free Research Field |
内分泌学
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