Do thyroid cancer risk factors FOXE1 and NKX2-1 influence risk of development of a benign adenoma?

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591369
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Nagasaki University
• Principal Investigator: SAENKO Vladimir 長崎大学, 原爆後障害医療研究所, 准教授 (30343346)
• Co-Investigator(Kenkyū-buntansha): NAKASHIMA Masahiro 長崎大学, 原爆後障害医療研究所, 教授 (50284683) ; MITSUTAKE Norisato 長崎大学, 原爆後障害医療研究所, 准教授 (50404215) ; ITO Masahiro 独立行政法人国立病院機構, 長崎医療センター 臨床検査科, 部長 (30184691)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 内分泌学 / 甲状腺腫瘍 / 遺伝子多型

Outline of Final Research Achievements

Association analysis of five SNPs previously reported to confer risk for thyroid cancer with benign follicular adenoma (FA) was performed in 959 FA, 535 papillary thyroid carcinomas (PTC), and 2766 population controls from Japan.
A significant association was found between FA and rs944289 (PTCSC3) and rs2439302 (NRG1), demonstrating that predisposing genetic factors are partly common for benign and malignant thyroid tumors, and implying broader roles of the pathways that NRG1 and PTCSC3 underlie in thyroid tumorigenesis, not limited to carcinogenesis.

Free Research Field

分子生物学、放射線影響学