Effects of innate immune activation induced by infection or tissue damage on the development of thyroid autoimmunity

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591375
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: SUZUKI Koichi 国立感染症研究所, 感染制御部, 室長 (20206478)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 甲状腺 / 自然免疫

Outline of Final Research Achievements

Rat thyroid FRTL-5 cells or primary culture of mouse thyroid cells were stimulated by electric pulse to induce cell damage, or transfected with human herpes virus genomic DNA or synthetic double-stranded polynuclerotides. After these treatments, expression of series of genes essential for innate and acquired immune responses was induced. However, thyroglobulin gene expression and iodine uptake were suppressed by these treatments. These results suggest that when immune functions of thyroid cells are activated upon infection or tissue damage, thyroid hormone biosynthesis may be suppressed. Further studies are needed to confirm this possibility.

Free Research Field

自己免疫、自然免疫、感染免疫