2014 Fiscal Year Final Research Report
Analysis of somatic mutation for adult T-cell leukemia using a next-generation sequencing
| Project/Area Number |
24591392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 成人T細胞白血病 / NF-kB |
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| Outline of Final Research Achievements |
To elucidate the molecular mechanism of NF-kB activation for adult T-cell leukemia (ATL), we examined somatic mutation of ATL cells using next-generation DNA sequencing. Among 27 ATL patients evaluated, there was no non-synonymous mutation for A20, BCL11B, CARD11, MYD88, or NIK. However, two patients with ATL had CARD11 mutation at coiled-coil domain (M360V, D401Y). These mutations showed NF-kB activation by luciferase reporter assay. CARD11 could contribute a constitutive activation of NF-kB for ATL.
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| Free Research Field |
血液内科学
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