2014 Fiscal Year Final Research Report
Analysis of the mechanisms of HSC maintenance and differentiation utilizing c-Myb reporter mice
| Project/Area Number |
24591400
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 血液幹細胞 / 転写因子 / c-myb |
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| Outline of Final Research Achievements |
We have established c-Myb reporter mice that can moniter the endogeous c-Myb protein. Utilizing the mice, we proved that c-Myb protein was able to control cell functions, especially HSCs, according to c-Myb expression levels. We have also confirmed the concepts of lineage-biased and dormant HSCs . We anticipate that these mice will become a new reserch tool that can efficiently isolate HSCs self-renewing from the embyonic to the adult stage.
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| Free Research Field |
医歯薬学
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