Regulation of Erythropoietin production and its roles on adult hematopoiesis

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591404
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Tohoku University
• Principal Investigator: MINEGISHI Naoko 東北大学, 東北メディカル・メガバンク機構, 教授 (40271895)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Mikiko 東北大学, 医学系研究科, 講師 (80508309)
• Research Collaborator: HIRANO Ikuo 東北大学, 大学院医学系研究科, 助教 (00708117) ; SUZUKI Norio 東北大学, 大学院医学系研究科, 講師 (20447254) ; SOUMA Tomokazu ; YAMAZAKI Shun
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 遺伝子発現制御 / エリスロポエチン / 赤血球造血 / 腎性貧血 / 転写因子 / 低酸素応答性

Outline of Final Research Achievements

Erythropoietin, secreted from adult kidney, is essential for erythropoiesis. We made ISAM (Inherited Super Anemic Mice), which exhibited Epo-deficient-anemia in their adulthood. We found the significantly decreased number of proerythroblasts and basophilic erythroblasts in their bone marrow, and several downstream-genes of Epo signals in bone marrow cells. Epo producing cells of ISAM were demonstrated as the cells expressing green fluorescence, among cortical fibroblasts in adult kidneys, and also in the portion of embryonic neural cells and neural crest cells. In the experimental fibrotic kidneys, Epo-producing cells transformed into myofibroblasts and halted Epo production. These changes were reversible. We have an impression that the inhibition of inflammatory signals might be a novel therapeutic strategy for renal fibrosis and renal anemia.

Free Research Field

血液内科学