2014 Fiscal Year Final Research Report
Establishment of tailor-made type allogeneic hematopoietic stem cell transplantation based on immune-modulating gene polymorphism analysis
| Project/Area Number |
24591418
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Aichi Medical University (2013-2014)
Kanazawa University (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 遺伝子多型 |
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| Outline of Final Research Achievements |
When the impact of immune-modulating gene polymorphisms was examined in patients and their donors of unrelated hematopoietic stem cell transplantation, genetic variations in the CXCL10, NLRP3, PTPN22, CD53, and THBD genes were associated with transplant outcomes. Experimental investigation revealed that the gene polymorphisms of NLRP3, CD53 and THBD play functionally important roles in the regulation of their production. These findings may offer clinical benefits in patients with receiving allogeneic hematopoietic stem cell transplants as well as those with autoimmune diseases, infectious diseases, cancers and receiving organ transplants.
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| Free Research Field |
血液内科
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